Efficient Tumor Immunohistochemistry: A Differential-Diagnosis Driven Approach
Overwhelmed by the growing number of immunohistochemical stains available? Taking a shotgun approach to staining and diagnosis? Caught in a confusing web of “positive” and “negative” staining results?

ASCP has published a book that will help pathologists narrow their choices to markers found useful by the surgical pathology staff at the University of Miami Jackson Memorial Hospital and Sylvester Comprehensive Cancer Center.

Efficient Tumor Immunohistochemistry: A Differential Diagnosis-Driven Approach, ASCP, 2006, is a practical reference guide written by Mehrdad Nadji, MD; Mehdi Nassiri, MD; and Azorides Morales, MD. The authors have a combined 60 years of experience in immunohistochemistry.

The book is a gold mine of images – 472 in all – depicting tissue samples prepared by traditional H&E methods and then treated with markers based on the pathologist's differential diagnosis. Brief text accompanying the images indicates the results of the tests, offers helpful hints about the technical or analytical aspects of the markers used, and reveals a final diagnosis.

“It takes you out of the maze of large antibody panels and streamlines the process,” said Dr. Nadji, Professor of Pathology and Director of Immunohistochemistry and at the University of Miami School of Medicine.

In their preface, the authors state that they adhere “to practicality as the single most important criterion in the resolution of daily diagnostic problems encountered by surgical pathologists.”

Efficient Tumor Immunohistochemistry is:

• A practical handbook with simple guidelines for resolving common and some uncommon diagnostic problems using a limited number of antibodies.
• Not an algorithm, but a tailor-made approach that requires the active participation of the practicing pathologist.

Mehrdad Nadji, MD
Dr. Nadji is a 1969 graduate of the University of Tehran School of Medicine in Tehran. From 1973 to 1977 he completed his residency in Anatomic and Clinical Pathology at the University of Miami, Jackson Memorial Medical Center. Thereafter, he joined the faculty of the Department of Pathology at the University of Miami School of Medicine. His areas of research interest include immunohistochemical and molecular biologic study of diagnostic and predictor markers of human solid tumors. Dr. Nadji is member of editorial boards of several pathology and cancer journals. He is author and co-author of 165 original scientific articles and 12 books or chapters. Dr. Nadji has more than 250 national and international invited lectureships and seminars, as well as visiting professorships.